Preprint
Spatial metabolic gradients in the liver and small intestine
Samarah LZ, Zheng C, Xing X, Lee WD, Afriat A, Chitra U, MacArthur M, Lu W, Jankowski CSR, Ma C, Hunter CJ, Raphael BJ, Rabinowitz JD.
bioRxiv 2025 Jun 2:2025.06.02.657306. doi: 10.1101/2025.06.02.657306.
Microengineered transplantation of human solid tumors for in vitro studies of CAR T immunotherapy
Liu H, Noguera-Ortega E, Dong X, Lee WD, Chang J, Aday Aydin S, Li Y, Shin Y, Shi X, Liousia M, Martinez MC, Brotman JJ, Kim S, Chen Z, Wang A, Ou Z, Paek J, Park JY, Liu A, Hu H, Xiao Z, Racca DM, Kim S, Worthen GS, Guo W, Puré E, Kang T, Rabinowitz JD, Wherry EJ, Moon EK, Albelda SM, Huh DD.
bioRxiv 2025 Apr 29:2025.04.25.650709. doi: 10.1101/2025.04.25.650709.
PMID: 39605668
Language model-guided anticipation and discovery of unknown metabolites
Qiang H, Wang F, Lu W, Xing X, Kim H, Merette SAM, Ayres LB, Oler E, AbuSalim JE, Roichman A, Neinast M, Cordova RA, Lee WD, Herbst E, Gupta V, Neff S, Hiebert-Giesbrecht M, Young A, Gautam V, Tian S, Wang B, Röst H, Greiner R, Chen L, Johnston CW, Foster LJ, Shapiro AM, Wishart DS, Rabinowitz JD, Skinnider MA.
bioRxiv. 2024 Nov 15:2024.11.13.623458. doi: 10.1101/2024.11.13.623458.
PMID: 39605668
A bioengineered model of human placental exposure to environmental metals during pregnancy
Fattahi P, Younesi M, Lee WD, Whang K, Kang T, Rabinowitz JD, Aleksunes LM, Huh DD
bioRxiv. 2024 Sep 11:2024.09.06.611636. doi: 10.1101/2024.09.06.611636
Peer-reviewed
2025
Microbiome metabolism of dietary phytochemicals controls the anticancer activity of PI3K inhibitors
Roichman A, Zuo Q, Hwang S, Lu W, Cordova RA, MacArthur MR, Boyer JA, Mitchell SJ, Powers J, Koval SA, Hunter CJ, Rijmers J, Ryseck RP, AbuSalim JE, Chatterjee S, Lee WD, Xu X, Xing X, Chen Z, Zeng X, Marwaha S, McBride MJ, Guo JY, Kang Y, Donia MS, Rabinowitz JD.
Cell. 2025 May 29;188(11):3065-3080.e21. doi: 10.1016/j.cell.2025.04.041. Epub 2025 May 19.
PMID: 40393457
Lactate homeostasis is maintained through regulation of glycolysis and lipolysis
Lee WD, Weilandt DR, Liang L, MacArthur MR, Jaiswal N, Ong O, Mann CG, Chu Q, Hunter CJ, Ryseck RP, Lu W, Oschmann AM, Cowan AJ, TeSlaa TA, Bartman CR, Jang C, Baur JA, Titchenell PM, Rabinowitz JD.
Cell Metab. 2025 Mar 4;37(3):758-771.e8. doi: 10.1016/j.cmet.2024.12.009. Epub 2025 Jan 30.
PMID: 39889702
2024
Quantification of nutrient fluxes during acute exercise in mice
Axsom J, TeSlaa T, Lee WD, Chu Q, Cowan A, Bornstein MR, Neinast MD, Bartman CR, Blair MC, Li K, Thorsheim C, Rabinowitz JD, Arany Z.
Cell Metab. 2024 Dec 3;36(12):2560-2579.e5. doi: 10.1016/j.cmet.2024.09.010. Epub 2024 Oct 15.
PMID: 39413791
Cardiac NAD+ depletion in mice promotes hypertrophic cardiomyopathy and arrhythmias prior to impaired bioenergetics
Doan KV, Luongo TS, Ts’olo TT, Lee WD, Frederick DW, Mukherjee S, Adzika GK, Perry CE, Gaspar RB, Walker N, Blair MC, Bye N, Davis JG, Holman CD, Chu Q, Wang L, Rabinowitz JD, Kelly DP, Cappola TP, Margulies KB, Baur JA.
Nat Cardiovasc Res. 2024 Oct;3(10):1236-1248. doi: 10.1038/s44161-024-00542-9. Epub 2024 Sep 18.
PMID: 39294272
NAD+ precursors prolong survival and improve cardiac phenotypes in a mouse model of Friedreich’s Ataxia
Perry CE, Halawani SM, Mukherjee S, Ngaba LV, Lieu M, Lee WD, Davis JG, Adzika GK, Bebenek AN, Bazianos DD, Chen B, Mercado-Ayon E, Flatley LP, Suryawanshi AP, Ho I, Rabinowitz JD, Serai SD, Biko DM, Tamaroff J, DeDio A, Wade K, Lin KY, Livingston DJ, McCormack SE, Lynch DR, Baur JA.
JCI Insight. 2024 Jul 18;9(16):e177152. doi: 10.1172/jci.insight.177152.
PMID: 39171530
Selected Ion Monitoring for Orbitrap-Based Metabolomics
Lu W, McBride MJ, Lee WD, Xing X, Xu X, Li X, Oschmann AM, Shen Y, Bartman C, Rabinowitz JD.
Metabolites. 2024 Mar 25;14(4):184. doi: 10.3390/metabo14040184.
PMID: 38668312
mTORC1 controls murine postprandial hepatic glycogen synthesis via Ppp1r3b
Uehara K, Lee WD, Stefkovich M, Biswas D, Santoleri D, Garcia Whitlock A, Quinn W 3rd, Coopersmith T, Creasy KT, Rader DJ, Sakamoto K, Rabinowitz JD, Titchenell PM.
J Clin Invest. 2024 Jan 30;134(7):e173782. doi: 10.1172/JCI173782.
PMID: 38290087
2023
Inferring mitochondrial and cytosolic metabolism by coupling isotope tracing and deconvolution
Stern A, Fokra M, Sarvin B, Alrahem AA, Lee WD, Aizenshtein E, Sarvin N, Shlomi T.
Nat Commun. 2023 Nov 18;14(1):7525. doi: 10.1038/s41467-023-42824-z.
PMID: 37980339
Dichloroacetate as a novel pharmaceutical treatment for cancer-related fatigue in melanoma
Zhang X, Lee WD, Leitner BP, Zhu W, Fosam A, Li Z, Gaspar RC, Halberstam AA, Robles B, Rabinowitz JD, Perry RJ.
Am J Physiol Endocrinol Metab. 2023 Oct 1;325(4):E363-E375. doi: 10.1152/ajpendo.00105.2023. Epub 2023 Aug 30.
PMID: 37646579
Tissue-specific reprogramming of glutamine metabolism maintains tolerance to sepsis
Leitner BP, Lee WD, Zhu W, Zhang X, Gaspar RC, Li Z, Rabinowitz JD, Perry RJ.
PLoS One. 2023 Jul 6;18(7):e0286525. doi: 10.1371/journal.pone.0286525. eCollection 2023.
PMID: 37410734
Impact of acute stress on murine metabolomics and metabolic flux
Lee WD, Liang L, AbuSalim J, Jankowski CSR, Samarah LZ, Neinast MD, Rabinowitz JD.
Proc Natl Acad Sci U S A. 2023 May 23;120(21):e2301215120. doi: 10.1073/pnas.2301215120. Epub 2023 May 15.
PMID: 37186827
Osteoblast-intrinsic defect in glucose metabolism impairs bone formation in type II diabetic male mice
Song F, Lee WD, Marmo T, Ji X, Song C, Liao X, Seeley R, Yao L, Liu H, Long F.
Elife. 2023 May 5;12:e85714. doi: 10.7554/eLife.85714.
PMID: 37144869
Slow TCA flux and ATP production in primary solid tumours but not metastases
Bartman CR, Weilandt DR, Shen Y, Lee WD, Han Y, TeSlaa T, Jankowski CSR, Samarah L, Park NR, da Silva-Diz V, Aleksandrova M, Gultekin Y, Marishta A, Wang L, Yang L, Roichman A, Bhatt V, Lan T, Hu Z, Xing X, Lu W, Davidson S, Wühr M, Vander Heiden MG, Herranz D, Guo JY, Kang Y, Rabinowitz JD.
Nature. 2023 Feb;614(7947):349-357. doi: 10.1038/s41586-022-05661-6. Epub 2023 Feb 1.
PMID: 36725930
2022
Circulating metabolite homeostasis achieved through mass action
Li X, Hui S, Mirek ET, Jonsson WO, Anthony TG, Lee WD, Zeng X, Jang C, Rabinowitz JD.
Nat Metab. 2022 Jan;4(1):141-152. doi: 10.1038/s42255-021-00517-1. Epub 2022 Jan 20.
PMID: 35058631
2021
Tumor Reliance on Cytosolic versus Mitochondrial One-Carbon Flux Depends on Folate Availability
Lee WD, Pirona AC, Sarvin B, Stern A, Nevo-Dinur K, Besser E, Sarvin N, Lagziel S, Mukha D, Raz S, Aizenshtein E, Shlomi T.
Cell Metab. 2021 Jan 5;33(1):190-198.e6. doi: 10.1016/j.cmet.2020.12.002. Epub 2020 Dec 15.
PMID: 33326752
2019
Studying metabolic flux adaptations in cancer through integrated experimental-computational approaches
Lagziel S, Lee WD, Shlomi T.
BMC Biol. 2019 Jul 4;17(1):51. doi: 10.1186/s12915-019-0669-x.
PMID: 31272436
Inferring cancer dependencies on metabolic genes from large-scale genetic screens
Lagziel S, Lee WD, Shlomi T.
BMC Biol. 2019 Apr 30;17(1):37. doi: 10.1186/s12915-019-0654-4.
PMID: 31039782
Spatial-fluxomics provides a subcellular-compartmentalized view of reductive glutamine metabolism in cancer cells
Lee WD, Mukha D, Aizenshtein E, Shlomi T.
Nat Commun. 2019 Mar 22;10(1):1351. doi: 10.1038/s41467-019-09352-1.
PMID: 30903027
2017
Diversity and abundance of human-pathogenic fungi associated with pigeon faeces in urban environments
Lee WD, Fong JJ, Eimes JA, Lim YW.
Mol Ecol. 2017 Sep;26(17):4574-4585. doi: 10.1111/mec.14216. Epub 2017 Jul 21.
PMID: 28636808
2014
A checklist of the basidiomycetous macrofungi and a record of five new species from mt. Oseo in Korea
Lee WD, Lee H, Fong JJ, Oh SY, Park MS, Quan Y, Jung PE, Lim YW.
Mycobiology. 2014 Jun;42(2):132-9. doi: 10.5941/MYCO.2014.42.2.132. Epub 2014 Jun 30.
PMID: 25071381